Leonardo Silva Santos et.al.: Investigation of chemical reactions in
solution using API-MS
- Author(s): Leonardo Silva Santos, Larissa Knaack, Juergen O. Metzger
- Title: Investigation of chemical reactions in solution using
API-MS
- Date of Upload: 2005
- Article: IJMS 246 (2005) 84–104, Institut f¨ur Reine und Angewandte
Chemie, Carl von Ossietzky Universit¨at, 26111 Oldenburg, Germany
- Keywords: Reaction mechanism; ESI-MS; APCI-MS; Microreactor;
On-line screening
- Abstract:
- The general concepts, advantages, and applications of on-line and off-line
screening to organic reaction mechanistic studies applying API-MS are
reviewed. An overview is presented of the development and the present stage of
connected microreactors to API ion-sources. Examples of the successful
application of API in revealing, elucidating, and helping to consolidate
several proposed mechanisms of organic reactions are summarized. Finally, a
variety of outstanding features and advantages that make API-MS the most
suitable tool for the fast screening of intermediates directly from solution,
and the exceptional gains in chemical information for organic chemists are
also emphasized.
- URL: http://www.chemie.uni-oldenburg.de/oc/metzger/publikationen/pdf/107.pdf
(application/pdf)
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