Leonardo Silva Santos et.al.: Investigation of chemical reactions in solution using API-MS

Author(s): Leonardo Silva Santos, Larissa Knaack, Juergen O. Metzger

Title: Investigation of chemical reactions in solution using API-MS

Date of Upload: 2005

Article: IJMS 246 (2005) 84–104, Institut f¨ur Reine und Angewandte Chemie, Carl von Ossietzky Universit¨at, 26111 Oldenburg, Germany

Keywords: Reaction mechanism; ESI-MS; APCI-MS; Microreactor; On-line screening

Abstract:
The general concepts, advantages, and applications of on-line and off-line screening to organic reaction mechanistic studies applying API-MS are reviewed. An overview is presented of the development and the present stage of connected microreactors to API ion-sources. Examples of the successful application of API in revealing, elucidating, and helping to consolidate several proposed mechanisms of organic reactions are summarized. Finally, a variety of outstanding features and advantages that make API-MS the most suitable tool for the fast screening of intermediates directly from solution, and the exceptional gains in chemical information for organic chemists are also emphasized.

URL: http://www.chemie.uni-oldenburg.de/oc/metzger/publikationen/pdf/107.pdf (application/pdf)


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